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Evidence - Uniportal VATS pneumonectomy right

  1. Summary of the literature

    Even in the early days of thoracic surgery, pneumonectomy held a special position, as the procedure had a 100 percent mortality rate. It was not until 1931 that the first documented successful pneumonectomy in a child after thoracic trauma was performed by Rudolph Nissen.

    Since then, not only surgical techniques but also anesthesia and intensive care medicine have significantly advanced. Nevertheless, the procedure remains an operation with considerable risks, a 30-day mortality rate of 5% to 12%, and a lifelong reduction in quality of life. Strict indication and selection of patients for the procedure is the most important factor. (3, 4)

    Considering the mostly malignant indication of advanced bronchial carcinoma, patients were predominantly grateful for the gained lifetime despite significant physical limitations. (5)

    It is therefore always necessary to check whether a parenchyma-sparing sleeve resection is possible. Current literature shows that a sleeve lobectomy ("sleeve resection") is associated with a significantly lower 30-day mortality rate between 0 and 4.3%. (6) Postoperative lung function and thus physical resilience are also significantly improved, which logically explains an increased quality of life. (5, 6)

    The original concerns about an increased rate of local recurrences have been clearly refuted by newer studies, provided that intraoperative frozen section diagnostics and strict indication are considered. (7)

  2. Currently ongoing studies on this topic

  3. Literature on this topic

    (1) Oncology Guidelines Program (German Cancer Society, German Cancer Aid, AWMF): Prevention, Diagnosis, Therapy, and Follow-up of Lung Cancer, Long Version 1.0, 2018, AWMF Registry Number: 020/007OL, http://leitlinienprogramm-onkologie.de/Lungenkarzinom.98.0.html (Accessed on: 01.04.2022)

    (2) Expertise in Thoracic Surgery. Müller M, Wanka S, Inderbitzi R, Kiefer T, Stubenberger E, Eds. 1st Edition. Stuttgart: Thieme; 2015.

    (3) Marc Riquet, Pierre Mordant, Ciprian Pricopi, Antoine Legras, Christophe Foucault, Antoine Dujon, Alex Arame, Françoise Le Pimpec-Barthes, A review of 250 ten-year survivors after pneumonectomy for non-small-cell lung cancer, European Journal of Cardio-Thoracic Surgery, Volume 45, Issue 5, May 2014, Pages 876–881, https://doi.org/10.1093/ejcts/ezt494

    (4) Warwick R, Mediratta N, Shackcloth M, Page R, McShane J, Shaw M, Poullis M. Pneumonectomy: risk factor or innocent bystander? Asian Cardiovasc Thorac Ann. 2014 Jan;22(1):49-54. doi: 10.1177/0218492313477102. Epub 2013 Sep 3. PMID: 24585644.

    (5) Balduyck B, Hendriks J, Lauwers P, Van Schil P. Quality of life evolution after lung cancer surgery: a prospective study in 100 patients. Lung Cancer. 2007 Jun;56(3):423-31. doi: 10.1016/j.lungcan.2007.01.013. Epub 2007 Feb 16. PMID: 17306905.

    (6) Park JS, Yang HC, Kim HK, Kim K, Shim YM, Choi YS, Kim J. Sleeve lobectomy as an alternative procedure to pneumonectomy for non-small cell lung cancer. J Thorac Oncol. 2010 Apr;5(4):517-20. doi: 10.1097/JTO.0b013e3181d0a44b. PMID: 20104190.

    (7) Maurizi G, D'Andrilli A, Anile M, Ciccone AM, Ibrahim M, Venuta F, Rendina EA. Sleeve lobectomy compared with pneumonectomy after induction therapy for non-small-cell lung cancer. J Thorac Oncol. 2013 May;8(5):637-43. doi: 10.1097/JTO.0b013e318286d145. PMID: 23584296.

  4. Guidelines

  5. literature search

    Literature search on the pages of pubmed.