Evidence - Diathermy excision / contact destruction of anal condylomata acuminata

The surgical treatment of condyloma by excision or local destruction (excision/destruction with scissors, diathermy, laser, or cryotherapy; scalpel excision) seems to deliver the best results with healing rates of up to 94% and a recurrence rate of 29% after three months. Diathermy tends to result in better data than cryotherapy. It should be noted that these are epidermal tumors. The destruction of deep skin layers does not offer any benefit in terms of radicality and prevention of recurrence. However, it risks functionally adverse scarring.

Carbon Dioxide Laser Ablation Versus Electrocoagulation - a Prospective, Randomized Multicenter Trial Comparing Two Surgical Treatments in Women Undergoing Therapy for Condyloma Acuminata

Adjuvant Imiquimod Therapy to Reduce Recurrence Rate in Patients After Surgical Therapy of Anal HPV (Human Papilloma Virus)-Lesions

Stone KM, Becker TM, Hadgu A et al.: Treatment of external genital warts: a randomised clinical trial
comparing podophyllin, cryotherapy, and electrodesiccation. Genitourin Med. 66, 16-19, 1990

Moore RA, Edwards JE, Hopwood J et al.: Imiquimod for the treatment of genital warts: a quantitative
systematic review. BMC Infect Dis 2001

Jensen SL: Comparison of podophyllin application with simple surgical excision in clearance and recurrence
of perianal condylomata acuminata. Lancet 2, 1146-1148, 1985

Khawaja HT: Podophyllin versus scissor excision in the treatment of perianal condylomata acuminata: a
prospective study. Br J Surg 76, 1067-1068, 1989

Prayogo SA, Andrew H, Cong S, Intaran KDA. Photodynamic therapy in the treatment of condyloma acuminata: A systematic review of clinical trials. Int J STD AIDS. 2023 Feb;34(2):76-86

Shen S, Feng J, Song X, Xiang W. Efficacy of photodynamic therapy for warts induced by human papilloma virus infection: A systematic review and meta-analysis. Photodiagnosis Photodyn Ther. 2022 Sep;39:102913.

Diţescu D, Istrate-Ofiţeru AM, Roşu GC, Iovan L, Liliac IM, Zorilă GL, Bălăşoiu M, Cercelaru L. Clinical and pathological aspects of condyloma acuminatum - review of literature and case presentation. Rom J Morphol Embryol. 2021 Apr-Jun;62(2):369-383.

Iranmanesh B, Khalili M, Zartab H, Amiri R, Aflatoonian M. Laser therapy in cutaneous and genital warts: A review article. Dermatol Ther. 2021 Jan;34(1):e14671

Sugai S, Nishijima K, Enomoto T. Management of Condyloma Acuminata in Pregnancy: A Review. Sex Transm Dis. 2021 Jun 1;48(6):403-409. 

2022 Asian guidelines for condyloma acuminatum

2021 CDC’s Sexually Transmitted Infections (STI) Treatment Guidelines

2019 European Guideline for the Management of Anogenital Warts