The pancreas is made of lobules and has a reddish-grey color, is 14 - 18 cm long and weighs 65 - 80 grams. It is located at the level of the first and second lumbar vertebrae and extends in a wedge shape from the epigastric region to the left hypochondriac region. Embryologically, the organ is situated in close relation with the upper abdominal organs and vessels.
The pancreas is invested by capsule-like connective and fatty tissue and is divided into three sections: Head, body, and tail. Whereas there is a somewhat firmer connective tissue lamina along the posterior aspect of the head, the gland is otherwise mainly loosely bound by connective tissue in the posterior region. As a retroperitoneal organ, the gland is overlaid by peritoneum on its anterior aspect.
The gland is widest at the head, which nestles within the curve of the duodenum just to the right of the spine. Both the anterior and posterior aspects of the duodenum may be overlaid to varying degrees by glandular tissue. The head, with its caudal portion (uncinate process), cradles the superior mesenteric vein from posteriorly and occasionally the artery as well. The notch in the uncinate process extending along the junction of the left half of the pancreatic head and the neck of the pancreas is known as incisura pancreatis.
With a width of approx. 2 cm, the region of the pancreas at the level of the first lumbar vertebra constitutes the transition zone between the head and body of the organ and is located craniad to the superior mesenteric vessels. From a surgical perspective, this is also known as the neck of the pancreas.
The elongated pancreatic body extends diagonally and upwards anterior to the first and second lumbar vertebra, protruding anteriorly into the lesser sac and arcing toward the splenic hilum; it transitions to the head without an exact anatomical delineation. The aorta, inferior vena cava, and superior mesenteric artery and vein are located posterior to the pancreas and adjacent to the spine.
The pancreatic tail constitutes the tapered continuation of the body and extends to or even into the splenorenal ligament.
The pancreatic anlage may take various shapes – oblique, S-shaped, transverse, and L-shaped. Horseshoe and inverted V-variants have also been described. The transition between these variant shapes is fluid.