Evidence - Standard bilioenteric anastomosis

  1. Literature summary

    The gold standard in bilioenteric anastomosis is end-to-side Roux-en-Y hepaticojejunostomy with a segment of the proximal jejunum.

    The successful outcome of hepatobiliary anastomosis is determined by the diameter of the bile duct and the section undergoing anastomosis. Another decisive factor is the fact if this is the first such procedure or revision surgery and if there is concomitant bile duct infection.

    In surgery of the biliary tract exact preoperative diagnostic work-up of the biliary tract anatomy is mandatory for low complication rates. In terms of afferent reconstruction techniques, hepaticojejunostomy has become the gold standard. Here, the preferred bilioenteric anastomosis is established proximal to the cystic duct origin and about 2-3 cm distal to the union of the hepatic ducts.

    The rationale for this level lies in the arterial perfusion of the CHD. A short ductal stump has better arterial perfusion than a long remnant. Due to tissue necrosis electrocautery should be used rather sparingly. Bleeding at the cystic duct/CHD should be controlled with thin suture-ligatures.

    When employing interrupted sutures some of the knots will be located within the lumen of the duct. Before completing the anterior wall, the patency of the anastomosis should always be verified (e.g., with Overholt forceps).

    Interrupted sutures seem to result in higher failure rates, while in running sutures the rate of stenosis is higher. However, there are no randomized trials studying this issue (interrupted or running sutures?).

    The anastomosis should be performed with thin absorbable monofilament sutures (PDS 5/0 or 6/0).

    Simultaneous injury of the CHD and the proper hepatic artery result in significantly higher failure rates of the hepaticojejunostomy.

    Creation of a so-called “inspection stoma” as a modified Roux-en-Y hepaticojejunostomy offers the opportunity for endoscopic and radiological follow-up after bile duct resection.

     This is indicated in complex bile duct injuries, tumor resections where the resection margin has not been confirmed clear of tumor, and recurrent intrahepatic sludge formation or cholelithiasis.

    Due to its present low complication rate and mortality, bilioenteric anastomosis in malignant bile duct obstruction offers highly effective palliation primarily in those patients who are in good general condition and without manifest distant metastasis. Compared with endoscopic procedures, the safe prevention of duodenal obstruction by combined gastroenterostomy and long-term bile drainage benefits particularly those patients with an expected survival longer than six months. However, the deciding factor for optimized palliation in each patient is the cooperative application of surgical and endoscopic techniques.

    In patients with postoperative changes in their anatomy, the rate of successful postoperative ERCP procedures is rather low. In these cases, ERCP can be complemented by single-balloon enteroscopy which offers a promising additional study modality with low complication rates. In most of these cases, ERCP with SBE-enhancement can help avoid more invasive procedures, such as PTC or surgery.

  2. Ongoing trials on this topic

  3. References on this topic

    Goumard C, Boleslawski E, Brustia R, Dondero F, Herrero A, Lesurtel M, Barbier L, Lecolle K, Soubrane O, Bouyabrine H, Mabrut JY, Salamé E, Cachanado M, Simon T, Scatton O. Duct-to-duct biliary reconstruction with or without an intraductal removable stent in liver transplantation: The BILIDRAIN-T multicentric randomised trial. JHEP Rep. 2022 Jul 6;4(10):100530

    Le Bot A, Sokal A, Choquet A, Maire F, Fantin B, Sauvanet A, de Lastours V. Clinical and microbiological characteristics of reflux cholangitis following bilio-enteric anastomosis. Eur J Clin Microbiol Infect Dis. 2022 Aug;41(8):1139-1143.

    Martinino A, Pereira JPS, Spoletini G, Treglia G, Agnes S, Giovinazzo F. The use of the T-tube in biliary tract reconstruction during orthotopic liver transplantation: An umbrella review. Transplant Rev (Orlando). 2022 Jul 7;36(4):100711.

    Calamia S, Barbara M, Cipolla C, Grassi N, Pantuso G, Li Petri S, Pagano D, Gruttadauria S. Risk factors for bile leakage after liver resection for neoplastic disease. Updates Surg. 2022 Oct;74(5):1581-1587.

    Ödemiş B, Başpınar B, Durak MB, Coşkun O, Torun S. Lumen reconstruction with magnetic compression anastomosis technique in a patient with complete esophageal stricture. Acta Gastroenterol Belg. 2022 Apr-Jun;85(2):393-395.

    Vest M, Ciobanu C, Nyabera A, Williams J, Marck M, Landry I, Sumbly V, Iqbal S, Shah D, Nassar M, Nso N, Rizzo V. Biliary Anastomosis Using T-tube Versus No T-tube for Liver Transplantation in Adults: A Review of Literature. Cureus. 2022 Apr 18;14(4):e24253.

    Yamaguchi N, Matsuyama R, Kikuchi Y, Sato S, Yabushita Y, Sawada Y, Homma Y, Kumamoto T, Takeda K, Morioka D, Endo I, Shimada H. Role of the Intramural Vascular Network of the Extrahepatic Bile Duct for the Blood Circulation in the Recipient Extrahepatic Bile Duct Used for Duct-to-Duct-Biliary-Anastomosis in Living Donor Liver Transplantation. Transpl Int. 2022 May 3;35:10276.

    Kim MS, Hong SK, Woo HY, Cho JH, Lee JM, Yoon KC, Choi Y, Yi NJ, Lee KW, Suh KS. Optimal Intervention for Initial Treatment of Anastomotic Biliary Complications After Right Lobe Living Donor Liver Transplantation. Transpl Int. 2022 Apr22;35:10044.

    Lee IJ, Lee JH, Kim SH, Woo SM, Lee WJ, Kang B, Kim HB. Percutaneous transhepatic treatment for biliary stricture after duct-to-duct biliary anastomosis in living  donor liver transplantation: a 9-year single-center experience. Eur Radiol. 2022  Apr;32(4):2414-2425.

    Fasullo M, Kandakatla P, Amerinasab R, Kohli DR, Shah T, Patel S, Bhati C, Bouhaidar D, Siddiqui MS, Vachhani R. Early laboratory values after liver transplantation are associated with anastomotic biliary strictures. Ann Hepatobiliary Pancreat Surg. 2022 Feb 28;26(1):76-83.

    Ma D, Liu P, Lan J, Chen B, Gu Y, Li Y, Yue P, Liu Z, Guo D. A Novel End-to-End Biliary-to-Biliary Anastomosis Technique for Iatrogenic Bile Duct Injury of Strasberg-Bismuth E1-4 Treatment: A Retrospective Study and in vivo Assessment. Front Surg. 2021 Oct 28;8:747304.

    Horacio J. Asbun, Asbun HJ. The SAGES Manual of Biliary Surgery. Cham: Springer International Publishing AG; 2020.

    Lillemoe KD, Jarnagin W. Hepatobiliary and Pancreatic Surgery. Philadelphia: Wolters Kluwer Health; 2013.

    Jarnagin W. Blumgart's surgery of the liver, biliary tract, and pancreas, 6th ed. Philadelphia, PA: Elsevier; 2017.

Reviews

Martinino A, Pereira JPS, Spoletini G, Treglia G, Agnes S, Giovinazzo F. The use  of the T-tube in

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